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应用小鼠急性毒性实验、大鼠与犬的亚急性毒性实验以及LD_(50)测定,对藻酸双酯钠毒理学进行了研究.结果表明,小鼠一次口服的LD_(50)为12 230.2mg/kg;在大鼠亚急性毒性实验中,三组用药大鼠(50mg/kg,428mg/kg,1070.2mg/kg)各脏器未发现与药物毒性有关的病理改变,外周血象和肝、肾功能也均为正常;犬的亚急性毒性实验发现,两用药组凝血时间较对照组显著延长(P<0.01),其中用药量为316.46mg/kg(1/8LD_(50))组犬的肝细胞多呈混浊肿胀,少数发生脂肪变性,肾近曲小管肿胀混浊.提示该药属微毒药品;大剂量长期使用对肝、肾有轻微毒性.
The acute toxicity test in mice, the subacute toxicity test in rats and dogs, and the determination of LD_(50) were used to study the toxicology of sodium alginate. The results showed that one oral dose of LD_(50) was 12 230.2. In the rat subacute toxicity test, no pathological changes associated with drug toxicity were found in the organs of the three groups of rats (50mg/kg, 428mg/kg, 1070.2mg/kg), peripheral blood and liver, The renal function was also normal. The subacute toxicity test of dogs showed that the coagulation time of the two drugs group was significantly longer than that of the control group (P<0.01), and the dose of the two drugs was 316.46 mg/kg (1/8LD_(50)) of the dogs. Most of the hepatocytes were turbid and swollen, a few had fatty degeneration, and the proximal tubules of the kidneys were swollen and turbid. This suggested that the drug was a micro-toxic drug; long-term use of large doses had slight toxicity to the liver and kidneys.