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目的探讨改良短时受精在体外受精-胚胎移植(IVF-ET)周期治疗中对胚胎质量的影响及其临床应用价值。方法回顾性分析2009年9月至2012年8月在唐山市妇幼保健院生殖中心接受体外受精助孕治疗的患者886例,其中短时受精不脱颗粒细胞组(A组)235例,短时受精并全部即刻脱颗粒细胞组(B组)315例,短时受精并部分(3~5枚)脱颗粒细胞组(C组)336例。分别比较3组的受精率、多精受精率、卵裂率、优质胚胎率、妊娠率、胚胎种植率和流产率。结果 3组的受精率、卵裂率、胚胎种植率和流产率差异无统计学意义(P>0.05);B组的多精受精率高于A、C两组(P<0.05);C组的优质胚胎率和临床妊娠率高于A、B两组(P<0.05)。结论短时受精并部分即刻脱颗粒细胞不影响受精率、卵裂率和胚胎种植率,但可提高优质胚胎率及临床妊娠率,并且能够降低多精受精率。
Objective To investigate the effect of improved short-term fertilization on embryo quality and its clinical value in IVF-ET cycle therapy. Methods A retrospective analysis of 886 cases of in vitro fertilization and pregnancy treatment in the reproductive center of Tangshan Maternal and Child Health Hospital from September 2009 to August 2012 was retrospectively analyzed. Among them, 235 cases of short-term non-detached granulocyte (A group) There were 315 cases of fertilized and all immediate degranulation (group B), 336 cases of short fertilization and some (3-5) degranulation cells (group C). The fertilization rate, fertilization rate, cleavage rate, quality embryo rate, pregnancy rate, embryo implantation rate and abortion rate were compared among the three groups. Results There was no significant difference in fertilization rate, cleavage rate, embryo implantation rate and miscarriage rate among the three groups (P> 0.05). The fertilization rate of group B was higher than that of group A and C (P <0.05) The high-quality embryo rate and clinical pregnancy rate were higher than those in A and B groups (P <0.05). Conclusion Short-term fertilization and partial immediate degranulation do not affect fertilization rate, cleavage rate and embryo implantation rate, but can improve the quality embryo rate and clinical pregnancy rate, and can reduce the fertilization rate.