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由于冠状动脉血管的堵塞会引起心肌梗死,使心肌梗死区的氧气及营养输送减少,从而导致大量心肌细胞的死亡及心功能的衰退。同时心肌组织缺乏再生能力,若受损后通过组织工程方法进行修复,则血管化在组织再生及修复中起着重要作用,因此在心肌组织血管化方面的突破将对缺血性心脏病的治疗带来深远的影响。当前心肌组织工程血管化的策略包括多学科方法,其中有工程材料和输送生长因子方法。伴随着对血管化生物学的更多了解,这些先进的方法促进了对组织再生和修复有治疗潜力的组织工程血管化策略的发展。本文从细胞治疗、支架设计及预血管化方面讨论心肌组织工程血管化的策略。
Because coronary artery occlusion causes myocardial infarction, oxygen and nutrient delivery in the infarcted area is reduced, leading to the death of a large number of cardiomyocytes and the decline of cardiac function. At the same time the lack of regenerative capacity of myocardial tissue, if damaged by tissue engineering methods of repair, then vascularization plays an important role in tissue regeneration and repair, and therefore a breakthrough in myocardial tissue vascularization will be the treatment of ischemic heart disease Bring far-reaching impact. Current strategies for myocardial tissue engineering vascularization include multidisciplinary approaches that include engineering materials and methods of delivering growth factors. Along with a greater understanding of vascularization biology, these advanced approaches have promoted the development of tissue engineering vascularization strategies that have the potential to regenerate tissue and repair it. This article discusses the strategy of myocardial tissue engineering vascularization from the aspects of cell therapy, stent design and pre-vascularization.