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最好认为恶性血管内皮细胞增生症(MAE)是一种淋巴结外的血管内淋巴瘤,或者是一种亲血管的大细胞淋巴瘤,该病以小血管内瘤性淋巴细胞增殖为特征,皮肤和中枢神经系统血管最常受累。该文3例患者经常规镜检和免疫组化分析肯定了MAE诊断,并对其中1例患者的皮损进行了分子遗传学分析和电镜研究。 病例1为74岁女性患者,腿部红色皮损10月,检查见双下肢及股部有红色坚实的皮下结节,结节活检示MAE变化;免疫组化证实血管内为B淋巴细胞浸润;分子遗传学研究示B
Malignant endothelium hyperplasia (MAE) is best thought to be an extranodal intravascular lymphoma or a pro-angiogenic large cell lymphoma that is characterized by the proliferation of small intravascular neoplastic lymphocytes, the skin And central nervous system blood vessels are most commonly involved. The three cases of patients confirmed by routine microscopic examination and immunohistochemical analysis of MAE, and one case of lesions were analyzed by molecular genetics and electron microscopy. Case 1 was a 74-year-old woman with a red skin lesion on the leg in October and a solid red subcutaneous nodule on both lower limbs and thighs. The nodule biopsy showed changes in the MAE. Immunohistochemistry confirmed the infiltration of B lymphocytes in the blood vessel. Molecular genetics research shows B