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目的探讨母血清白细胞介素 6 (IL 6 )、C 反应蛋白 (CRP)与早产亚临床绒毛膜羊膜炎的关系。方法用酶联免疫吸附实验测定6 7例早产孕妇及 32例相同孕周正常孕妇血IL 6 ,同时测定血CPR、白细胞计数 (WBC)。结果早产组血IL 6WBC明显高于对照组(P <0 .0 5 ) ,但两组间CRP浓度无显著性差异 (P >0 .0 5 )。胎膜早破早产与胎膜完整早产血IL 6、CPR无显著性差异 (P >0 .0 5 )。组织学绒毛膜羊膜炎阳性组血清IL 6、CRP均明显高于组织学绒毛膜羊膜炎阴性组 (P<0 .0 1) ,IL 6≥ 10pg/ml、CPR >8.2 0mg/l对预测亚临床绒毛膜羊膜炎的敏感性和准确性分别为 88.89%、80 .6 0 %和 5 2 .78%、6 4.18%。结论母血IL 6CRP均是预测早产亚临床绒毛膜羊膜炎较有用的指标 ,但IL 6比CRP具有更高的敏感性和准确性。
Objective To investigate the relationship between maternal serum interleukin 6 (IL 6), C-reactive protein (CRP) and subclinical chorioamnionitis in preterm labor. Methods 酶 Methods Sixty-seven preterm pregnant women and 32 pregnant women of the same gestational age were tested for serum IL-6 by enzyme-linked immunosorbent assay (ELISA), and the blood count (CPR) and white blood cell count (WBC) were measured simultaneously. Results The serum IL-6WBC in preterm labor group was significantly higher than that in control group (P <0.05), but there was no significant difference in CRP concentration between the two groups (P> 0.05). Premature rupture of membranes and premature rupture of membranes IL 6, CPR no significant difference (P> 0.05). The serum levels of IL-6 and CRP in histological chorioamnionitis positive group were significantly higher than those in histological chorioamnionitis negative group (P <0.01), IL 6≥10 pg / ml and CPR> 8.2 0mg / The sensitivity and accuracy of clinical chorioamnionitis were 88.89%, 80.60% and 52.28%, respectively, 6.41%. Conclusion Milum blood IL 6CRP is a more useful predictor of subclinical chorioamnionitis, but IL 6 is more sensitive and accurate than CRP.