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成年人在30岁以后垂体分泌的生长激激(GH)量逐渐减少。因血GH浓度在24小时内有很大波动,故作者采用测定胰岛素样生长因子(IGF-1,亦即生长介素C)来间接推断血GH含量。文献报道20～40岁的健康男子中,95%以上血浆IGF-1含量超过350U/L,而在60岁以上的男子中30%IGF-1含量低于比值。血浆IGF-1含量低可能是老年人肌肉重量减少,脂肪重量增加之故。为论证这一假设,作者观察21名年龄为61～81岁的男子。前6个月进行全面体格检查和血浆IGF-1测定。第7个月起随机分为两组。对照组9人,平均68岁,平均体重为理想体重的105%;观察组12人,平均67岁,
The amount of growth hormone (GH) secreted by the pituitary after 30 years of age in adults is gradually reduced. Because of the large fluctuations in serum GH concentrations within 24 hours, the authors indirectly infer blood GH levels by measuring insulin-like growth factor (IGF-1, also known as Interleukin-C). It has been reported in the literature that more than 95% of plasma IGF-1 levels in healthy men aged 20 to 40 exceed 350 U / L, whereas 30% of IGF-1 levels in men over the age of 60 are below the ratio. Low plasma IGF-1 levels may be due to decreased muscle mass in the elderly and increased fat mass. To demonstrate this hypothesis, the authors observed 21 men aged 61-81. Overall physical examination and plasma IGF-1 measurement were performed 6 months prior. From the seventh month, they were randomly divided into two groups. The control group of 9, average 68 years old, the average body weight of 105% of ideal body weight; observation group of 12, average 67 years old,