,Targeting peptide-decorated biomimetic lipoproteins improve deep penetration and cancer cells acces

• 作 者: Tao Tan Yuqi Wang Jing Wang Zhiwan Wang Hong Wang Haiqiang Cao Jie Li Yaping Li Zhiwen Zhang Siling Wang
• 机 构: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China“,”State Key Laborator
• 出 处: 药学学报（英文版）
• 发表日期: 2020年3期
• 关键词: Lipoprotein Drug deliver Tumor penetration Nanoparticles Cancer therapy

The limited penetration of nanoparticles and their poor accessibility to cancer cell fractions in tumor remain essential challenges for effective anticancer therapy.Herein,we designed a targeting peptide-decorated biomimetic lipoprotein (termed as BL-RD) to enable their deep penetration and efficient accessibility to cancer cell fractions in a tumor,thereby improving the combinational chemophotodynamic therapy of triple negative breast cancer.BL-RD was composed of phospholipids,apolipoprotein A1 mimetic peptide (PK22),targeting peptide-conjugated cytotoxic mertansine (RM) and photodynamic agents of DiIC18(5) (DiD).The counterpart biomimetic lipoprotein system without RM (termed as BL-D) was fabricated as control.Both BL-D and BL-RD were nanometer-sized particles with a mean diameter of less than 30 nm and could be efficiently intealized by cancer cells.After intravenous injection,they can be specifically accumulated at tumor sites.When comparing to the counterpart BL-D,BL-RD displayed superior capability to permeate across the tumor mass,extravasate from tumor vasculature to distant regions and efficiently access the cancer cell fractions in a solid tumor,thus producing noticeable depression of the tumor growth.Taken together,BL-RD can be a promising delivery nanoplatform with prominent tumor-penetrating and cancer cells-accessing capability for effective tumor therapy.