A new method for the synthesis of 3-hydroxymethylbenzofuran

• 作 者: Huan Luo Yan-Fei Liu Chun-Lei Zhang Yan Wang Gang Ni De-Quan Yu
• 机 构: State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia M
• 出 处: Chinese Chemical Letters
• 发表日期: 2013年12期
• 关键词: intramolecular hydrochloric cyclization acidic benzofuran diluted hydroxyl remov

A new one-step synthesis of 3-hydroxymethylbenzofuran,based on intramolecular cyclization of 2-(methoxymethyl)-2-(20-methoxymethyl-40-methylphenyl)-butanone 1 under diluted hydrochloric acid in THF,was developed.The mechanism for this process was investigated via chemical equilibrium shift of tautomer in acidic conditions.The applicability of this new method was studied further in this paper.

A new one-step synthesis of 3-hydroxymethylbenzofuran, based on intramolecular cyclization of 2- (methoxymethyl) -2- (20-methoxymethyl-40-methylphenyl) -butanone 1 under diluted hydrochloric acid in THF, was developed. The mechanism for this process was investigated via chemical equilibrium shift of tautomer in acidic conditions. The applicability of this new method was studied further in this paper.