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目的 探讨早期干预对减少中重度缺氧缺血性脑病 (HIE)患儿脑瘫、精神发育迟滞等后遗症的作用。方法 将 118例中重度HIE患儿依家长意见分为干预组 (A组 ) 6 6例及对照组 (B组 ) 5 2例。对A组从 1个月起进行早期干预至 2 4个月。结果 2 4个月时A组及B组患儿智能发育指数 (MDI)分别为 93 5 1± 17 35和 84 5 9±2 1 14,运动发育指数 (PDI)分别为 91 5 6± 2 2 31和 79 98± 30 5 0。 2 4个月时两组患儿MDI、脑瘫、PDI异常及社会适应异常发病例数分别为 6和 12 ,3和 8,7和 15 ,8和 14。A组明显好于B组 (P <0 0 5 )。结论 对HIE患儿进行早期干预能显著减少脑瘫、智能发育迟滞等后遗症的发生 ,改善其预后
Objective To investigate the effect of early intervention on reducing sequelae such as cerebral palsy and mental retardation in children with moderate and severe hypoxic-ischemic encephalopathy (HIE). Methods According to the opinions of parents, 118 cases of moderate and severe HIE children were divided into intervention group (A group) and control group (B group), 56 cases. Group A from the early intervention from 1 month to 24 months. Results At 24 months, the MDIs of group A and group B were 93 5 1 ± 17 35 and 84 5 9 ± 2 1 14 respectively, and the motor developmental indices (PDIs) were 91 5 6 ± 2 2 31 and 79 98 ± 30 5 0. At 24 months, the incidences of MDI, cerebral palsy, PDI abnormalities and abnormal social adaptation in the two groups were 6 and 12, 3 and 8, 7 and 15, 8 and 14, respectively. Group A was significantly better than group B (P <0 05). Conclusion Early intervention in children with HIE can significantly reduce the occurrence of sequelae, such as cerebral palsy and delayed mental retardation, and improve their prognosis