论文部分内容阅读
目的探讨血浆基质金属蛋白酶9(MMP-9)水平在急性脑梗死出血转化中的临床意义。方法 157例发病24h内急性脑梗死患者,根据是否存在出血转化分为脑梗死组(梗死组,135例)和脑梗死出血转化组(转化组,22例);于起病24h急诊行血浆MMP-9水平测定,并分析其与脑梗死出血转化、梗死体积大小和病情严重程度的相关性。结果转化组血浆MMP-9水平高于梗死组(P<0.01);梗死体积大者血浆MMP-9水平也明显高于中、小梗死者(P<0.01);NIH卒中量表(NIHSS)评分≥7分者血浆MMP-9的含量亦明显上调(P<0.01)。结论血浆MMP-9水平与脑梗死出血转化的发生及梗死体积大小、病情严重程度相关。脑梗死早期检测血浆MMP-9可作为临床预测脑梗死出血转化的参考指标。
Objective To investigate the clinical significance of plasma matrix metalloproteinase 9 (MMP-9) level in acute cerebral infarction hemorrhage. Methods Fifty-seven patients with acute cerebral infarction within 24 hours of onset were divided into cerebral infarction group (135 cases) and cerebral infarction group (22 cases) by the presence or absence of hemorrhage. Plasma MMP -9 levels, and analyze the correlation with the hemorrhagic transformation of cerebral infarction, infarct size and the severity of the disease. Results The level of plasma MMP-9 in the transformed group was significantly higher than that in the infarcted group (P <0.01). The plasma level of MMP-9 in the infarcted volume group was also significantly higher than that in the moderate and small infarct group (P <0.01). NIHSS score The plasma MMP-9 level of ≥7 points was also significantly increased (P <0.01). Conclusion The plasma level of MMP-9 is related to the occurrence of cerebral infarction hemorrhage and the size of infarction and the severity of the disease. The detection of plasma MMP-9 in the early stage of cerebral infarction can be used as a reference index for clinically predicting the hemorrhage of cerebral infarction.