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目的探讨慢性胃炎患者采用奥美拉唑及克拉霉素联合治疗的临床疗效及安全性分析。方法选取我院收治的120例慢性胃炎患者,随机分为观察组和对照组,每组60例,观察组采用奥美拉唑及克拉霉素联合治疗,对照组仅采用奥美拉唑进行治疗。结果观察组的总有效率高于对照组患者,χ2=6.987 8,P<0.01,差异具有统计学意义;两组均肝、肾功能治疗前后无显著变化,均无严重不良反应发生。结论奥美拉唑及克拉霉素联合慢性胃炎患者的临床疗效优于单用奥美拉唑,且不良反应轻微,有助于加快患者的康复及提高生活质量。
Objective To investigate the clinical efficacy and safety of omeprazole combined with clarithromycin in patients with chronic gastritis. Methods A total of 120 chronic gastritis patients admitted to our hospital were randomly divided into observation group and control group, 60 cases in each group. Omeprazole and clarithromycin were used in the observation group and omeprazole alone in the control group . Results The total effective rate in the observation group was higher than that in the control group (χ2 = 6.987 8, P <0.01). There was no significant difference between the two groups before and after the treatment of liver and kidney function, and no serious adverse reactions occurred. Conclusion The clinical efficacy of omeprazole and clarithromycin in combination with chronic gastritis is superior to omeprazole alone with mild adverse reactions, which can help to speed up the patient’s recovery and improve the quality of life.