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目的观察吉西他滨灌注治疗腺性膀胱炎的临床效果和安全性。方法 41例腺性膀胱炎患者依据治疗方法分为2组,对照组21例行经尿道电切术,联合组20例于经尿道电切术后1～2d给予吉西他滨0.4g膀胱灌注,之后膀胱灌注1次/周,连续灌注6次后改为2周1次,共治疗8次。术后3个月评定2组疗效并进行比较。结果联合组治疗有效率为95.0%,对照组为61.9%,2组比较差异有统计学意义(P<0.05)。结论经尿道电切联合吉西他滨膀胱灌注是治疗腺性膀胱炎的有效方法。
Objective To observe the clinical effect and safety of gemcitabine in the treatment of glandular cystitis. Methods Forty-one patients with glandular cystitis were divided into two groups according to the treatment method. Twenty-one patients in the control group underwent transurethral resection of the urethra, and 20 patients in the combined group received gemcitabine 0.4g intravesical instillation 1 ~ 2 days after transurethral resection. Perfusion 1 times / week, continuous perfusion 6 times changed to 2 weeks 1 times, a total of 8 treatments. Three months after surgery, the two groups were evaluated and compared. Results The effective rate was 95.0% in the combined group and 61.9% in the control group. There was significant difference between the two groups (P <0.05). Conclusion Transurethral resection combined with gemcitabine intravesical instillation is an effective method for the treatment of cystitis glandularis.