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目的 :探讨支气管哮喘患者病程的长短与体内 β肾上腺素能受体 (β adrenocepter,βAR)水平的关系。方法 :用同位素放射免疫配基法对不同病程的支气管哮喘患者外周血淋巴细胞 βAR的密度和亲和力进行检测 ,并就病程的长短与体内 βAR水平的关系作相关性分析。 结果 :支气管哮喘患者病程与体内 βAR密度呈显著负相关 ,相关系数为 - 0 5 3;与体内 βAR亲和力亦呈显著负相关 ,相关系数为 -0 6 1。结论 :支气管哮喘患者病程越长 ,体内 βAR水平越低。
Objective: To investigate the relationship between the duration of bronchial asthma and β adrenergic receptor (βAR) levels in patients with bronchial asthma. Methods: The density and affinity of βAR in peripheral blood lymphocytes of bronchial asthma patients with different course of disease were detected by radioimmunoassay. The relationship between the duration of disease and the level of βAR in vivo was analyzed. Results: There was a significant negative correlation between the course of disease and the βAR density in patients with bronchial asthma. The correlation coefficient was -0.53. There was also a significant negative correlation with the βAR affinity, with a correlation coefficient of -0.61. Conclusion: The longer duration of bronchial asthma patients, the lower the level of βAR in vivo.