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1973年Wvbran等发现了一种对绵羊红细胞(SRBC)有高度亲和力的T细胞亚群,称其为“活性的”或“早期的”T细胞。它具有在短时间(5分钟)内与SRBC结合形成花环的能力,而全部T细胞花环的形成却需要60分钟以上的时间。1977年West等证明,由于温度以及淋巴细胞与SRBC比例的不同,T细胞对SRBC具有不同的结合能力,因此分为两类:在29℃,并以有限的SRBC与淋巴细胞结合时,形成“高亲和力”的E花环(E-RFC);而在4℃,应
In 1973 Wvbran et al. Found a subset of T cells that are highly affinitive to sheep erythrocytes (SRBC), calling them “active” or “early” T cells. It has the ability to form a rosette in combination with SRBC in a short period of time (5 minutes), whereas the formation of all T-cell rosette takes more than 60 minutes. In 1977, West et al. Demonstrated that T cells have different binding capacity to SRBC due to temperature and the ratio of lymphocytes to SRBC. Therefore, T cells are divided into two types: at 29 ° C and with limited SRBC bound to lymphocytes, High-affinity "E-rosette (E-RFC); and at 4 ° C, should