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目的观察双歧杆菌四联活菌片预防婴幼儿化脓性脑膜炎继发腹泻的作用。方法 138例化脓性脑膜炎患儿随机分为预防组70例和对照组68例。两组均给以常规治疗,预防组在此基础上口服双歧杆菌四联活菌片,疗程7～14d。对比两组的腹泻及重型腹泻发生率。结果预防组继发腹泻10例,发生率15.7%,对照组继发腹泻36例,发生率52.9%,两组比较有统计学意义(P<0.01)。预防组发生重型腹泻1例,对照组发生重型腹泻12例,发生率33.3%,两组比较差异有统计学意义(P<0.05)。结论化脓性脑膜炎患儿服用双歧杆菌四联活菌片可以明显降低继发性腹泻的发生率,即使继发腹泻者,其严重程度明显减轻。
Objective To observe the role of Bifidobacterium quadriceps in preventing secondary diarrhea in infantile suppurative meningitis. Methods 138 cases of children with purulent meningitis were randomly divided into prevention group of 70 cases and control group of 68 cases. Both groups were given conventional treatment, prevention group on the basis of oral Bifidobacterium tetra live viable tablets, treatment of 7 ~ 14d. The incidence of diarrhea and severe diarrhea in both groups was compared. Results In the prevention group, 10 cases of secondary diarrhea occurred, the incidence rate was 15.7%. In the control group, 36 cases were secondary to diarrhea. The incidence rate was 52.9%. There was significant difference between the two groups (P <0.01). There was 1 case of severe diarrhea in prevention group and 12 cases of severe diarrhea in control group, the incidence rate was 33.3%. There was significant difference between the two groups (P <0.05). Conclusions Children with purulent meningitis treated with live Bifidobacterium quadriceps can significantly reduce the incidence of secondary diarrhea, even if secondary diarrhea, the severity was significantly reduced.