论文部分内容阅读
目的观察注射用头孢匹胺钠与甲硝唑注射液临床配伍的稳定性。方法按临床两药配伍习惯,将头孢匹胺钠与甲硝唑注射液按比例配制的待测溶液,于20℃密闭放置0、0.5、1、2、4h,对其进行溶液外观、pH值和紫外吸收光谱检查,并在波长273nm、320nm、359.5nm处,应用双波长紫外分光光度法同时测定头孢匹胺钠与甲硝唑的含量。结果在0～4h内,溶液外观、pH值和紫外吸收光谱基本不变化,头孢匹胺钠与甲硝唑的含量没有明显的变化。结论注射用头孢匹胺钠与甲硝唑注射液配伍在本次实验观察的范围内是稳定的。
Objective To observe the stability of clinical compatibility between cefpiramide sodium injection and metronidazole injection. Methods according to the clinical compatibility of the two drugs, cefpiramide sodium and metronidazole injection proportionally prepared test solution, at 20 ℃ placed 0,0.5,1,2,4 h, the solution appearance, pH value And UV absorption spectroscopy, and at the wavelength of 273nm, 320nm, 359.5nm, the simultaneous determination of cefpiramide sodium and metronidazole using dual-wavelength UV spectrophotometry. Results Within 0 ~ 4h, the appearance, pH and UV absorption spectra of the solution did not change, and the content of cefpiramide sodium and metronidazole did not change significantly. Conclusion The injection of cefpiramide sodium and metronidazole injection compatibility in this experimental range is stable.