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目的:观察投氟后不同给药组的大鼠血清中肌酐(creatimine Cr)、尿素氮(Urearutrogen BUN)、丙二醛(MDA)、超氧化物歧化酶(SOD)等水平变化。方法:48只SD大鼠,随机分为四组。给大鼠饮水投氟(每升水含氟150mg)10周,检测不同组大鼠血清中Cr、BUN、MDA、SOD的水平变化。结果:高氟组随着大鼠体内氟含量的蓄积,血清中的MDA有明显的上升趋势。血清中SOD的含量逐渐降低。与高氟组比较给予药物六妙散干扰组血清中MDA、SOD有明显差异。Cr、BUN含量高氟组与六妙散干扰组比较,数据有明显差异(P<0.05)六妙散组对氟中毒大鼠的肾功有明显的保护作用。结论:六妙散影响了氟中毒大鼠血清中MDA、SOD的含量,对氟中毒造成的肾损伤有保护作用。
Objective: To observe the changes of creatimine Cr, urea nitrogen (Urerutrogen BUN), malondialdehyde (MDA) and superoxide dismutase Methods: 48 SD rats were randomly divided into four groups. Rats were drenched with fluoride (150mg per liter of water fluoride) for 10 weeks to detect the changes of serum Cr, BUN, MDA and SOD in different groups. Results: With the increase of fluoride content in high fluoride group, MDA in serum increased obviously. Serum SOD content gradually decreased. Compared with the high fluoride group, the content of MDA and SOD in the serum of the intervention group was significantly different. There was significant difference between the high fluoride group and the Liumiaosan casualty group (P <0.05). The Liumiaosan group had significant protective effect on renal function of rats with fluorosis. Conclusion: Liu Miao San affected the content of MDA and SOD in the serum of fluorosis rats, and had a protective effect on kidney damage caused by fluorosis.