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目的比较双环醇片对乙型肝炎病毒B、C基因型感染的疗效。方法选择乙型肝炎病毒B基因型感染者26例、C基因型感染者44例,同时给予双环醇片口服,50mg/次,每日3次,疗程24周。观察受试者的临床症状、体征变化,并于治疗前、治疗期间(第12周)及治疗结束时(第24周),分别检测血常规、肝功能、乙肝三系和血清HBVDNA水平。结果双环醇片能明显改善B、C基因型乙型肝炎病毒感染者的临床症状和肝功能,并有一定的抑制病毒作用,两组患者治疗24周时的血清HBVDNA阴转率分别为19.2%和15.9%,差异无统计学意义。结论双环醇片不仅能保护慢性乙型肝炎患者的肝功能,同时能抑制乙型肝炎病毒复制,对B、C基因型乙型肝炎病毒感染者的疗效相近。
Objective To compare the curative effect of bicyclol tablets on hepatitis B and C genotypes. Methods Twenty-six patients with genotype B hepatitis B and 44 genotype C infection were treated with bicyclic alcohol 50 mg once daily for 24 weeks. The clinical symptoms and signs of the subjects were observed. Before and after treatment (week 12) and the end of treatment (week 24), the blood routine, liver function, hepatitis B trio and serum HBVDNA levels were detected. Results Bicyclomethanol tablets can significantly improve the clinical symptoms and liver function of patients with B and C genotypes of hepatitis B virus infection and have a certain effect of inhibiting the virus. The serum HBVDNA negative conversion rates of the two groups were 19.2% And 15.9%, the difference was not statistically significant. Conclusion Bicyclol can not only protect the liver function of patients with chronic hepatitis B, but also inhibit the replication of hepatitis B virus, and have similar curative effect on patients with B and C genotypes of hepatitis B virus infection.