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本文研究毒毛旋花子甙K(以下简称K)对视网膜的毒理作用。12只新西兰兔分为3组,分别于一侧眼玻璃体内注射K水溶液1、3或9 μg(0.1 ml)另一眼同法注射溶剂作对照,观察给药前后闪光视网膜电图(F-ERG)和瞳孔直接对光反射的变化。给药后,K使兔F-ERG的a、b波振幅呈剂量依赖性不同程度地下降,给药组与对照组有显著差异(p<0.01)。9 μg组给药后5h a、b波振幅已降至噪声水平,且在给药后3ha波达峰时间有
In this paper, toxic hair spinosad K (hereinafter referred to as K) on the toxicological effects of the retina. Twelve New Zealand rabbits were divided into three groups, one was injected intravitreally with 1, 3 or 9 μg (0.1 ml) aqueous K solution, and the other was injected with the same method as control. The changes of flash electroretinogram (F-ERG ) And pupil direct changes in light reflection. After administration, the amplitude of a, b wave of rabbit F-ERG decreased in a dose-dependent manner, and there was a significant difference (p <0.01) between the two groups. At 9h after administration, the amplitude of a and b wave decreased to the noise level at 5h after administration, and reached the peak at 3ha after administration