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目的:探讨健脾汤对大肠癌发生的影响,观察健脾汤对于二甲基肼诱发的昆明种小鼠大肠癌的预防作用。方法:选择昆明种小鼠为实验对象,予以DMH30mg/kg,皮下注射,每周2次,连续给药11周。再将小鼠分为治疗组、预防组、化疗组、对照组,24周处死小鼠。观察肿瘤的发生率,小鼠的一般状态、体重增长,以及肝、肺等病理变化。结果:24周时,预防组小鼠肿瘤平均荷瘤率为5.20,同治疗组、化疗组、对照组比较,有显著差异(P<0.01)。预防组小鼠脾指数11.74+1.45,也同其余组有明显差异。结论:健脾汤能够抑制DMH诱发的实验性小鼠大肠癌的发生和发展。
Objective: To investigate the effect of Jianpi Decoction on colorectal cancer and to observe the preventive effect of Jianpi Decoction on colorectal cancer induced by dimethylhydrazine in Kunming mice. Methods: Kunming mice were selected as experimental subjects and given DMH30mg / kg subcutaneously twice a week for 11 weeks. Mice were divided into treatment group, prevention group, chemotherapy group and control group, mice were sacrificed 24 weeks later. Observe the incidence of cancer, the general status of mice, weight gain, and liver, lung and other pathological changes. Results: At 24 weeks, the average tumor-bearing rate of mice in prevention group was 5.20, which was significantly different from that in the treatment group, the chemotherapy group and the control group (P <0.01). Prevention group mice spleen index 11.74 +1.45, but also with the remaining groups were significantly different. Conclusion: Jianpi Decoction can inhibit the occurrence and development of colorectal cancer induced by DMH in experimental mice.