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目的:研究转移抑制基因 nm~(23)在胃癌中的表达及其临床意义。方法:免疫组化采用链菌素亲生物素一过氧化物酶法(简称 S—P 法)。结果:nm~(23)表达阳性与胃癌淋巴结转移之间有显著相关性(P<0.05);5年随访资料证实 nm~(23)表达与患者预后有非常显著意义(P<0.01)。结论:提示 nm~(23)基因产物的表达可作为一个有用的预后指标,对临床具有一定的指导意义。
Objective: To study the expression of metastasis suppressor gene nm23 in gastric carcinoma and its clinical significance. Methods: Streptavidin-peroxidase (S-P method) was used for immunohistochemistry. Results: The positive expression of nm23 was significantly correlated with lymph node metastasis in gastric cancer (P<0.05). The 5-year follow-up data confirmed that the expression of nm23 was significantly associated with the prognosis of patients (P<0.01). Conclusion: It is suggested that the expression of nm23 gene product can be used as a useful prognostic indicator, which has a certain guiding significance for the clinic.