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目的:研究花脸蘑多糖对四氯化碳(CCl4)诱发的急性肝损伤的保护作用。方法:用CCl4建立小鼠急性化学性肝损伤模型,检测花脸蘑多糖对血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)活性及白蛋白(Alb)含量、肝组织超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、还原型谷胱甘肽(GSH)及丙二醛(MDA)的含量的影响。结果:花脸蘑多糖明显降低急性肝损伤小鼠血清ALT及AST活性,提高Alb含量及肝组织SOD、GSH-Px活力和GSH含量,并显著降低MDA含量。结论:花脸蘑多糖具有一定的肝保护作用,其机制可能与抗氧化作用有关。
Objective: To study the protective effect of Polygonum multiflorum polysaccharides on acute liver injury induced by carbon tetrachloride (CCl4). Methods: Acute chemical liver injury model was established in mice with CCl4. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and albumin (Alb) were measured. The content of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione (GSH) and malondialdehyde (MDA) Results: Mushroom polysaccharides significantly reduced serum ALT and AST activity in mice with acute liver injury, increased Alb content and liver SOD, GSH-Px activity and GSH content, and significantly reduce the MDA content. Conclusion: Polygonatum polysaccharides have a certain degree of liver protection, and its mechanism may be related to antioxidant effects.