论文部分内容阅读
目的：探讨亚低温对重度一氧化碳（ＣＯ）中毒脑损伤的治疗作用。方法：１３６例重度ＣＯ中毒患者随机分为亚低温组（６９例）和对照组（６７例），亚低温组在传统综合治疗的基础上给予亚低温治疗，对照组仅给予传统综合治疗；两组患者均进行格拉斯哥昏迷计分（ＧＣＳ）、比较死亡人数及迟发性脑病（ＤＥＡＣＭＰ）人数。结果：亚低温组在第 ３、４、５天 ＧＣＳ明显高于对照组（Ｐ＜０．０５）；亚低温组死亡率为１．４５％，ＤＥＡＣＭＰ发生率为７．２５％，均低于对照组的１１．９４％和１９．４０％（Ｐ＜０．０５）。结论：亚低温对重度 ＣＯ中毒脑损伤有明显的保护作用，能有效地降低死亡率及 ＤＥＡＣＭＰ的发生率。
Objective: To investigate the therapeutic effect of mild hypothermia on brain injury induced by severe carbon monoxide (CO) poisoning. Methods: One hundred and sixty-six patients with severe CO poisoning were randomly divided into mild hypothermia group (n = 69) and control group (n = 67). The mild hypothermia group was treated with mild hypothermia on the basis of traditional comprehensive treatment, while the control group only received traditional comprehensive treatment. Glasgow Coma Scores (GCS) were performed in all patients, comparing the number of deaths and the number of patients with delayed encephalopathy (DEACMP). Results: The GCS of hypothermia group was significantly higher than that of control group on the 3rd, 4th, 5th day (P <0.05). The mortality rate of hypothermia group was 1.45%, and the incidence of DEACMP was 7.25% The control group, 11.94% and 19.40% (P <0.05). Conclusion: Mild hypothermia has a significant protective effect on brain injury induced by severe CO poisoning, which can effectively reduce the mortality and the incidence of DEACMP.