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目的:研究医学影像数据存储及传输系统(PACS)诊断结果联合肿瘤标记物对肝癌(PHC)早期诊断的应用。方法:以PACS系统对20例PHC患者X线计算机体层摄影术(CT)、磁共振成像(MRI)影像学的资料进行收集,并与血清甲胎蛋白(AFP)、糖类抗原199(CA199)、糖类抗原125(CA125)及癌胚抗原(CEA)等血清性肿瘤标记物测定的结合,对临床PHC进行联合诊断。结果:CT、MRI扫描的检出阳性率为85.0%,显著高于AFP的55.0%,CEA的30.0%,CA199的50%,CA125的40.0%;AFP、CA199、CA125及CEA的灵敏度分别为60.0%、45.5%、44.4%、33.3%,特异度分别为50.0%、44.4%、27.3%、18.2%,联合检测中,4类指标联合CT、MRI检测的灵敏度及特异度均最高,分别为94.4%,83.3%。结论:以PACS系统对PHC患者CT、MRI影像学的资料进行收集分析,并与AFP、CA199、CA125及CEA等血清性肿瘤标记物测定相结合,更利于临床诊断,值得推荐。
Objective: To study the application of medical imaging data storage and transmission system (PACS) combined with tumor markers in the early diagnosis of hepatocellular carcinoma (PHC). Methods: X-ray computed tomography (CT) and magnetic resonance imaging (MRI) data of 20 patients with PHC were collected by PACS system, and were compared with serum alpha-fetoprotein (AFP), carbohydrate antigen 199 ), Carbohydrate antigen 125 (CA125) and carcinoembryonic antigen (CEA) and other serum tumor markers combined with the clinical diagnosis of PHC. Results: The positive rate of CT, MRI scan was 85.0%, significantly higher than 55.0% of AFP, 30.0% of CEA, 50% of CA199 and 40.0% of CA125; the sensitivity of AFP, CA199, CA125 and CEA were 60.0 The sensitivity and specificity of the four kinds of indexes combined with CT and MRI in the combined detection were the highest, 94.4% and 44.3% respectively, the specificity was 50.0%, 44.4%, 27.3% and 18.2% respectively %, 83.3%. Conclusion: The data of CT and MRI imaging of PHC patients collected by PACS system are collected and analyzed, and combined with the determination of serum tumor markers such as AFP, CA199, CA125 and CEA, which is more conducive to clinical diagnosis and is worth recommending.