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目的:观察坎地沙坦西酯对慢性心力衰竭病人心功能的治疗作用。方法:选择慢性心力衰竭病人80例。随机分为两组,对照组使用依那普利、氢氯噻嗪及地高辛等;治疗组加用坎地沙坦西酯。对治疗前后两组间临床资料进行比较。结果:治疗组和对照组总有效率分别为87.5%、75%;两组比较无统计学意义(P>0.05)。治疗组心功能NYHA分级好转率优于对照组(P<0.05);左室舒张末期内径(LVDD)缩小(P<0.01),左室射血分数(LVEF)增加(P<0.05),比较有统计学意义,6 min步行试验治疗组距离明显长于对照组(P<0.01)。结论:用坎地沙坦西酯治疗慢性心力衰竭明显优于常规治疗.可显著改善心力衰竭病人临床症状。
Objective: To observe the therapeutic effect of candesartan cilexetil on heart function in patients with chronic heart failure. Methods: 80 patients with chronic heart failure were selected. Randomly divided into two groups, the control group enalapril, hydrochlorothiazide and digoxin; treatment group with candesartan cilexetil. Before and after treatment of clinical data between the two groups were compared. Results: The total effective rate in treatment group and control group was 87.5% and 75% respectively. There was no significant difference between the two groups (P> 0.05). The NYHA grade improved rate in the treatment group was better than that in the control group (P <0.05). Left ventricular end-diastolic diameter (LVDD) decreased (P <0.01) and left ventricular ejection fraction (LVEF) increased Statistical significance, 6 min walk test treatment group was significantly longer than the control group (P <0.01). Conclusions: Candesartan cilexetil treatment of chronic heart failure is superior to conventional treatment, which can significantly improve the clinical symptoms of patients with heart failure.