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背景:胰岛素抵抗可能是高血压的危险因素,但不同种族人群中胰岛素抵抗与高血压的关系不一致。目的:分析蒙古族人群胰岛素抵抗与高血压的关系。设计:现况调查。单位:哈尔滨医科大学公共卫生学院流行病教研室。对象:2001年6月在现况调查基础上,选择内蒙古通辽市科左后旗部分原发性高血压患者和血压正常者,均为蒙古族,进一步核实并测量血压,签署知情同意书后纳入本调查,排除其他心血管疾病患者。入选对象共232人,年龄30～60岁。方法:采取整群抽样的方法,选取原发性高血压患者115人、血压正常者117人作为调查对象。采用标准化方法测量身高、体质量、腰围和臀围,腰臀比即腰围/臀围。体质量指数<24kg/m2或腰臀比<0.9,即体质量或体型偏于正常。应用血糖仪测定血糖,应用放射免疫法测定胰岛素和C-肽,胰岛素抵抗程度以胰岛素敏感指数来评价,胰岛素敏感指数=-ln眼血糖穴mmol/L雪×胰岛素穴mU/L雪演。考虑到体质量指数和腰臀比对胰岛素敏感指数的影响,将体质量指数穴≥24kg/m2和<24kg/m2雪、腰臀比穴≥0.9和<0.9雪分层后,进行统计学分析。主要观察指标:两组调查对象的胰岛素敏感指数。结果:纳入调查对象232人,全部进入结果分析,无脱落。①两组调查对象胰岛素敏感指数比较:高血压组的胰岛素敏感指数略低于血压正常组,但差异无显著性意义眼-3.56±0.27,-3.50±0.20(P>0.05)演。②按体质量指数和腰臀比分层后两组调查对象胰岛素敏感指数比较:当体质量指数<24时,高血压组胰岛素敏感指数显著低于血压正常组眼-3.56±0.27,-3.48±0.17(F=5.037熏P<0.05)演;当腰臀比<0.9时,高血压组的胰岛素敏感指数显著低于血压正常组眼-3.57±0.27,-3.49±0.20(F=4.537熏P<0.05)演。结论:在蒙古族非肥胖人群中,胰岛素抵抗与原发性高血压的发生可能有关。
Background: Insulin resistance may be a risk factor for hypertension, but insulin resistance is not consistent with hypertension in different ethnic groups. Objective: To analyze the relationship between insulin resistance and hypertension in Mongolian population. Design: current situation investigation. Unit: Department of Epidemiology, School of Public Health, Harbin Medical University. PARTICIPANTS: In June 2001, on the basis of the current situation survey, some patients with essential hypertension and normal blood pressure were selected from Kezuohouqi of Tongliao City, Inner Mongolia. All of them were Mongolian, and their blood pressure was further verified and measured. After informed consent was signed, Investigation, excluding other cardiovascular disease patients. A total of 232 selected objects, aged 30 to 60 years old. Methods: A cluster sampling method was used to select 115 patients with essential hypertension and 117 with normal blood pressure as subjects. Using a standardized method to measure height, body mass, waist circumference and hip circumference, waist-to-hip ratio, waist circumference / hip circumference. Body mass index <24kg / m2 or waist-hip ratio <0.9, that is, body mass or body size is normal. Blood glucose was measured with a blood glucose meter. The levels of insulin and C-peptide were measured by radioimmunoassay. The degree of insulin resistance was evaluated by insulin sensitivity index. Insulin sensitivity index = -ln eye blood glucose hole mmol / L snow × insulin mU / L snow show. Considering the influence of body mass index and waist-to-hip ratio on insulin sensitivity index, the body mass index points (≥24kg / m2 and <24kg / m2 snow, waist and hip ratio ≥0.9 and <0.9 snow stratification were statistically analyzed . MAIN OUTCOME MEASURES: Insulin sensitivity index of two groups of subjects. Results: 232 respondents were enrolled in the study, all of them were included in the result analysis without falling off. ① Comparison of insulin sensitivity index between two groups: Insulin sensitivity index of hypertension group was slightly lower than that of normotensive group, but there was no significant difference between the two groups (-3.56 ± 0.27, -3.50 ± 0.20, P> 0.05). ②Compared with the insulin sensitivity index of the two groups after body mass index and waist-hip ratio stratification, the insulin sensitivity index of hypertension group was significantly lower than that of normal control group (-3.56 ± 0.27, -3.48 ± 0.17 (F = 5.037 smoked P <0.05). When the WHR was less than 0.9, the insulin sensitivity index of hypertension group was significantly lower than that of normotensive patients (-3.57 ± 0.27, -3.49 ± 0.20, F = 4.537, P < 0.05) play. Conclusion: Among Mongolian non-obese people, insulin resistance may be related to the occurrence of essential hypertension.