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9-(2-磷酸甲氧乙基)-2,6-二氨基嘌呤(PMEDAP)是无环核苷酸类化合物,结构上与9-(2-磷酸甲氧乙基)腺嘌呤(PMEA)相似,具有更广更强的抗病毒活性,尽管其有一定的细胞毒性,在抗病毒感染及抗肿瘤等领域仍具有开发前景。本文概括了近20年来PMEDAP及其部分取代的衍生物在抗逆转录病毒(如艾滋病毒等)、肝炎病毒(如人和鸭乙肝病毒等)、疱疹病毒(如简单疱疹病毒1型和2型、人类疱疹病毒6、7、8型等)和其他动植物病毒(如香蕉条纹病毒、腺病毒等)活性的研究进展。PMEDAP在具有广谱抗病毒作用的同时,具有一定的细胞毒性,在抗肿瘤方面有很高的研究意义。本文综述了PMEDAP在抗肿瘤方面的研究进展及其可能的作用机制,并根据现有的构效研究对PMEDAP在抗病毒和抗肿瘤两个方向的进一步研究提出了展望。
9- (Methoxyethyl-2-methylethyl) -2,6-diaminopurine (PMEDAP) is an acyclic nucleotide compound that is structurally related to 9- (2-methoxymethoxyethyl) adenine (PMEA) Similar, with a broader and stronger antiviral activity, despite its certain cytotoxicity, in the areas of anti-viral infection and anti-tumor still has development prospects. This article summarizes the recent 20 years of PMEDAP and its partially substituted derivatives in antiretroviral (such as HIV), hepatitis (such as human and duck hepatitis B virus, etc.), herpes simplex virus (such as herpes simplex virus type 1 and type 2 , Human herpes virus 6,7,8 type) and other animal and plant viruses (such as banana streak virus, adenovirus, etc.) activity. PMEDAP possesses a certain degree of cytotoxicity while having a broad spectrum of antiviral activity and has a high research significance in anti-tumor. This review summarizes the research progress of PMEDAP in anti-tumor and its possible mechanism. According to the existing structure-activity studies, the future research on PMEDAP in both antiviral and anti-tumor directions is also presented.