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目的 :研究阿米替林 (amitriptyline ,Ami)对大鼠局灶性脑缺血 再灌注损伤的保护作用。方法 :6 0只大鼠分 6组。除假手术组 ,其余 5组分别用线栓法建立大鼠局灶性脑缺血 再灌注损伤模型 ,其中 4组在缺血前 2h分别腹腔注射 3个不同剂量Ami,即 2 0mg·kg-1,15mg·kg-1,10mg·kg-1,及Nim 2mg·kg-1,观察损伤脑组织含水量及生化的改变。结果 :Ami可明显减少脑组织含水量及丙二醛 (malondialdehyde ,MDA)含量 ,并增加超氧化物歧化酶 (su peroxiddismutase ,SOD)的活性。结论 :Ami对脑缺血 再灌注损伤具有明显保护作用 ,其机制与抗脂质过氧化有关
Objective: To study the protective effect of amitriptyline (Ami) on focal cerebral ischemia-reperfusion injury in rats. Methods: Sixty rats were divided into six groups. In addition to the sham operation group, the other 5 groups were established by focal cerebral ischemia-reperfusion injury model, including 4 groups before ischemia 2h were injected intraperitoneally three different doses of Ami, that is 20 mg · kg- 1, 15 mg · kg-1, 10 mg · kg-1, and Nim 2 mg · kg-1 respectively. The changes of water content and biochemistry in injured brain tissue were observed. Results: Ami significantly reduced brain water content and malondialdehyde (MDA) content, and increased superoxide dismutase (SOD) activity. Conclusion: Ami has a significant protective effect on cerebral ischemia-reperfusion injury, and its mechanism is related to anti-lipid peroxidation