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目的探讨大肠癌旁移行粘膜胚胎性癌抗原表达的意义。方法用免疫组化PAP法测CEA和免疫金银法测谷胱苷肽S_转移酶(GST_π)在52例大肠癌,34例癌旁粘膜以及35例正常粘膜组织中的抗原表达情况。结果移行粘膜CEA和GST_π的阳性表达率分别为32.8%和44.1%,与正常粘膜(阳性率分别为5.7%和11.8%)和大肠癌(阳性率分别为86.5%和96.1%)相比,均有显著性差异(P<0.05)。结论移行粘膜有去分化趋势,有潜在恶性
Objective To investigate the significance of the expression of mucosal embryonic carcinoma antigens in colorectal cancer. Methods The expression of glutathione S-transferase (GST_π) was detected by immunohistochemical PAP and CEA and immunogold-silver assay in 52 cases of colorectal carcinoma, 34 cases of paraneoplastic mucosa and 35 cases of normal mucosa. Results The positive expression rates of transitional mucosa CEA and GST_π were 32.8% and 44.1%, respectively, with normal mucosa (positive rate 5.7% and 11.8%, respectively) and colorectal cancer (positive rate were 86.6%. There was a significant difference between 5% and 96.1% (P<0.05). Conclusion There is a trend of dedifferentiation in transitional mucosa, which is potentially malignant