论文部分内容阅读
目的了解系统糖皮质激素治疗前后大疱性类天疱疮(BP)患者糖尿病患病情况及临床特点。方法回顾性分析2005年6月-2016年2月北京医院皮肤科和北京大学第三医院皮肤科收治的45例BP患者的临床资料,并与同期90例接受系统性应用糖皮质激素治疗的湿疹患者进行对照分析。结果系统性应用糖皮质激素治疗前,BP组与湿疹组诊断为2型糖尿病者与非2型糖尿病者的性别构成和年龄组成及2型糖尿病患病比例的差异均无统计学意义(P均>0.05)。系统性应用糖皮质激素治疗8周后,BP组诊断为2型糖尿病者平均年龄较非糖尿病者大(P<0.05),性别差异无统计学意义(P>0.05),且BP组患糖皮质激素诱导性糖尿病(GC-DM)比例较湿疹组高(P<0.05),BP组和湿疹组患GC-DM者均较未患GC-DM者的年龄大(P<0.05)。有代谢综合征病史的BP患者较无该病史者更易发生GC-DM(P<0.05)。结论 BP患者较湿疹患者更易发生GC-DM,且年龄越大的BP患者和既往有代谢综合症病史的BP患者更易发生GC-DM。
Objective To investigate the prevalence of diabetes and its clinical features in patients with bullous pemphigoid (BP) before and after systemic glucocorticoid therapy. Methods The clinical data of 45 patients with BP admitted to Department of Dermatology, Peking University Hospital and Peking University Third Hospital from June 2005 to February 2016 were retrospectively analyzed and compared with 90 patients receiving systemic glucocorticoid eczema Patients were controlled. Results Before the systemic glucocorticoid treatment, there were no significant differences in the gender composition and age composition and the prevalence of type 2 diabetes among patients with type 2 diabetes mellitus and those with type 2 diabetes mellitus > 0.05). After 8 weeks of systemic glucocorticoid therapy, the mean age at diagnosis of type 2 diabetes mellitus was significantly higher in BP group than in non-diabetic patients (P <0.05), and there was no significant difference in gender (P> 0.05) The ratio of hormone-induced diabetes mellitus (GC-DM) was higher than that of eczema patients (P <0.05). The BP-induced and GC-DM patients were higher than those without GC-DM (P <0.05). BP patients with a history of metabolic syndrome were more likely to develop GC-DM than those without this history (P <0.05). Conclusions GC patients with BP are more likely to develop GC-DM than those with eczema, and GC-DM is more likely to occur in older BP patients and in BP patients with a history of metabolic syndrome.