氧化应激与心血管疾病的新进展(续前)

• 作 者: 张刘锋
• 出 处: 中华高血压杂志
• 发表日期: 2010年02期
• 关键词: 氧化应激 心血管疾病 超氧化物 高血压模型 自发性颅内出血 主动脉狭窄 活性氧 血管紧张素 氧化酶活性 细胞外基质

2.4因果关系小鼠和人类实验表明,氧化应激与钙化性主动脉狭窄密切相关。目前需要弄清楚的问题是:是氧化应激导致或加重了主动脉狭窄(可能通过氧化还原敏感基因调节纤维化和钙化),还是主动脉狭窄加重了氧化应激。我们最初的研究表明,主动脉瓣膜在狭窄前,超氧化物表达就明显增加,

2.4 Causality Mouse and human experiments show that oxidative stress and calcification aortic stenosis are closely related. At present, the question to be clarified is whether oxidative stress leads to or aggravates aortic stenosis (possibly through the regulation of fibrosis and calcification by redox-sensitive genes), or aggravates oxidative stress through aortic stenosis. Our initial study showed that the aortic valve before stenosis, superoxide expression was significantly increased,