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Objective:This study aimed to introduce and evaluate a new embolization technique for the right gastric artery(RGA)during percutaneous implantation of a port-catheter system for hepatic arterial infusion chemotherapy(HAIC).Methods:From January 2013 to January 2017,159 patients with unresectable advanced liver cancer underwent percutaneous implantation of a port-catheter system.In 86 of these patients(56 men;aged 28-88 years;mean:60.6±12.0 years),in whom the RGA was obvious on arteriography,embolization of RGA was attempted using microcoils to protect the gastric mucosa during HAIC.In the first phase(first three years),antegrade embolization of the RGA using a 2.7 Fr microcatheter was performed in 55 patients.In the second phase(next two years),embolization of the RGA was attempted by combining antegrade embolization and retrograde embolization through the left gastric artery(LGA)in 31 patients.The success rates and the incidence of acute gastroduodenal mucosal toxicity(AGMT)in these two groups were compared.Results:The total success rate of the RGA embolization was 70.9％.The success rate was 83.9％in 31 patients who underwent combined antegrade and retrograde embolization,which was significantly higher than that of ante-grade embolization alone(63.6％)performed in 55 patients(p = 0.047).No complications related to embolization of RGA were documented.The incidence of AGMT was 29.1％(16/55)in patients in the first phase,which was significantly higher than that in the patients in the second phase(9.7％,3/31)(p = 0.037).Conclusion:A combination of retrograde embolization via LGA could increase the success rates of RGA emboli-zation and reduce the incidence of AGMT after HAIC.