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目的：探讨阿托伐他汀钙对人脐静脉内皮细胞（HUVEC）adropin表达的影响。方法不同浓度的阿托伐他汀钙（0.002、0.02、0.2、2和20μmol/L）与HUVEC共培养6、12和24 h。采用MTT法检测HUVEC的增殖情况。半定量逆转录聚合酶链反应（RT-PCR）检测HUVEC adropin mRNA的表达。ELISA法测定细胞上清液中adropin的浓度。结果阿托伐他汀钙在0.002～20μmol/L范围均能促进HUVEC的增殖，20μmol/L（与对照组比较P＜0.05）和24 h（与6 h时比较P＜0.05）时作用最强。阿托伐他汀钙呈浓度依赖性和时间依赖性增加了adropin mRNA的表达和培养上清液中adropin蛋白的浓度，在20μmol/L（与对照组比较P＜0.01）和24 h（与6 h时比较P＜0.01）作用最强。HUVEC上清液中adropin蛋白浓度与反映细胞增殖的OD值呈明显正相关（12 h，P=0.001；24 h，P＜0.001）。结论阿托伐他汀钙在一定范围内能够促进HUVEC adropin相关基因及蛋白的表达，且呈剂量和时间依赖性。“,”Objective To evaluate the effects of atorvastatin on mRNA and protein expression of adropin in cultured human umbilical vein endothelial cells (HUVEC). Methods HUVEC was cultured in vitro with atorvastatin of 0.002, 0.02, 0.2, 2 and 20 μmol/L for 6, 12 and 24 hours. The proliferation of HUVEC was detected by MTT chromatometry. RT-PCR and ELISA were performed to present the expression of adropin mRNA and adropin protein respectively. Results The proliferation of HUVEC was promoted after co-incubation with atorvastain from 0.002 to 20μmol/L concentration, and the peak was at 20μmol/L (versus control, P<0.05) and 24 h (versus 6 h, P<0.05). Atorvastatin upregulated the expression of adropin mRNA and adropin protein dose-dependently and time-dependently in HUVEC with a peak at 20μmol/L (versus control, P<0.01) and 24 h (versus 6 h, P<0.01). Adropin protein concentration in culture medium was positively correlated with the OD value indicating proliferation at 12 h (P=0.001) and 24 h (P<0.001) after co-incubation. Conclusion Atorvastatin can promote the expression of adropin dose-dependently and time-dependently in HUVEC at an appropriate range of concentration.