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1,6-二磷酸果糖为葡萄糖代谢过程中的一种重要中间产物,近年已日益广泛地应用于心血管病领域。为了探讨它对心衰患者左室收缩功能的影响,我们对14例不同程度的心衰患者,一次性给予1,6-二磷酸果糖后,用超声心动图测量其用药后15、30、60、120min的心排出量,射血分数及左室短轴缩短率,并与用药前相比较。发现患者的上述指标从15min始就明显增加,60min左右达最高峰值,120min开始有所下降,但仍保持在较高水平,药物有效作用时间持续2h以上。
Fructose 1, 6-diphosphate is an important intermediate in glucose metabolism and has been increasingly used in cardiovascular diseases in recent years. In order to explore its impact on left ventricular systolic function in patients with heart failure, 14 patients with different degrees of heart failure, after a one-time administration of fructose 1, 6-diphosphate, echocardiography measured after its use 15,30,60 , 120min cardiac output, ejection fraction and left ventricular fractional shortening, compared with before treatment. Found that the above indicators in patients from 15min began significantly increased, 60min or so reached the peak, 120min began to decline, but remained at a high level, the effective duration of the drug sustained 2h or more.