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目的 探讨血清胆碱酯酶(CHE)与动脉粥样硬化性脑梗死的关系.方法 收集2014年1月—2015年12月住院急性脑梗死患者212 例,其中大动脉粥样硬化型(LAA)103 例,穿支动脉病型(PAD)109 例.健康体检者50 名为对照组.测定两组CHE、同型半胱氨酸(Hcy)、空腹血糖(FBG)、低密度脂蛋白胆固醇(LDL)、尿酸(UA)、C-反应蛋白(CRP).结果脑梗死组血压、CHE、Hcy、FBG均高于对照组(P＜0.01);Logistic分析显示收缩压、CHE、Hcy、FBG的OR大于1(P均＜0.05);LAA组CHE、Hcy、LDL、NIHSS评分均高于PAD组( P＜0.05).结论CHE升高可能是脑梗死发病的又一危险因素,与病情严重程度相关.“,”Objective To investigate the relationship between serum cholinesterase (CHE) and atherosclerotic cerebral infarction. Methods 212 patients with acute cerebral infarction hospitalized in Suzhou Municipal Hospital from January 2014 to December 2015 were collected, including 103 patients with large artery atherosclerosis (LAA) and 109 patients with perforating artery disease (PAD). 50 healthy persons were taken as control group. CHE, homocysteine (Hcy), fasting blood glucose (FBG), low density lipoprotein cholesterol (LDL), uric acid (UA) and C-reactive protein (CRP) were measured. Results Blood pressure, CHE, Hcy and FBG in cerebral infarction group were higher than those in control group (P＜0.01); Logistic analysis showed that OR of systolic blood pressure, CHE, Hcy and FBG were higher than 1 (P＜0.05); CHE, Hcy, LDL and NIHSS scores in LAA group were higher than those in PAD group (P＜0.05). Conclusion Elevated CHE may be another risk factor for cerebral infarction, which is related to the severity of the disease.