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自从本栏于上次以促钠尿房肽(ANP)为题发表评述后,两年来变化很大。合成房肽的问世掀起一阵活跃,这反映在大量的原始报告,许多篇综述文章,还至少有三次国际专题讨论会。所有这些反响都适当否? 据实验室动物试验及对人体的研究,现已明确,心房肽是由心脏分泌,在血内循环,被体内各种组织迅速从血浆内去除。特异性的高亲和力受体已在血管、肾及肾上腺组织内检出。房肽存在于脑组织内,其密集区似与血压调节作用和血容量的体内稳定有关。心脏分泌和存
This column has changed dramatically in the past two years since the last review was made on the topic of promoting natriuretic peptide (ANP). The advent of synthetic atrial fibrillation set off a burst of activity, which is reflected in a large number of original reports, many articles, there are at least three international symposiums. All of these responses are appropriate? According to laboratory animal tests and human studies, it has been clear that atrial peptides are secreted by the heart, circulating in the blood, the body was quickly removed from the plasma of various tissues. Specific high-affinity receptors have been detected in blood vessels, kidneys and adrenal glands. Peptides present in the brain tissue, the dense zone and blood pressure may play a role in the regulation of the stability of blood volume in vivo. Heart secretion and deposit