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1,本文叙述从3-苯基丙醇的3′,5′-二硝基苯甲酸酯借 Wohl-Ziegler 溴化反应合成 1-苯基-1,3-丙二醇。2.用相同方法从3-(邻取代基-对硝基苯基)-丙醇酯合成1-(邻取代基-对硝基苯基)-1,3-丙二醇的相应的衍生物。此方法各步产量较高,可以用作在连于苯环的碳原子上引入一个羟基的制备方法。3.含氨基的化合物进行 Wohl-Ziegler 溴化反应时,最好用邻苯二甲酰基,保护氨基。4.3-溴代-3-(邻苯二甲酰亚氨-对硝基苯基)-丙醇乙酸酯在乙酸氢溴酸混合液中水解,获得7-硝基喹啉。
1. This paper describes the synthesis of 1-phenyl-1,3-propanediol from 3’-5’-dinitrobenzoate of 3-phenylpropanol using the Wohl-Ziegler bromination reaction. 2. The corresponding derivative of 1- (o-substituted-p-nitrophenyl) -1,3-propanediol was synthesized from 3- (o-substituted-p-nitrophenyl) -propanol ester in the same manner. This method has higher yield in every step and can be used as a preparation method for introducing a hydroxyl group on the carbon atom connected to the benzene ring. 3. Amino-containing compounds When carrying out the Wohl-Ziegler bromination reaction, it is preferred to use phthaloyl groups to protect the amino groups. 4.3. Bromo-3- (phthalimido-p-nitrophenyl) -propanol acetate is hydrolyzed in a mixture of hydrobromic acid acetate to give 7-nitroquinoline.