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目的 :观察抑癌基因 nm 2 3和突变型 P5 3癌基因在胃肠腺癌中的表达及其与临床病理特征的关系。方法 :用 SP免疫组化法观察 62例胃肠腺癌标本 nm 2 3、P5 3的表达。结果 :nm2 3阴性表达与胃肠腺癌浸润深度、分化程度无关 ( P>0 .0 5 ) ,而与淋巴转移有关 ( P<0 .0 1) ;P5 3过表达与肿癌的浸润深度、分化程度相关 ( P<0 .0 1) ,与淋巴转移无关 ( P >0 .0 5 )。结论 :nm2 3、P5 3与胃肠腺癌临床病理特征有一定关系
Objective: To observe the expression of tumor suppressor gene nm23 and mutant P53 oncogene in gastrointestinal adenocarcinoma and its relationship with clinicopathological features. Methods: Immunohistochemical SP method was used to observe the expression of nm23 and P53 in 62 cases of gastrointestinal adenocarcinoma. RESULTS: The negative expression of nm23 was not associated with the invasive depth and differentiation of gastrointestinal adenocarcinoma (P>0.05), but was associated with lymphatic metastasis (P<0.01); P53 overexpression and tumor invasion depth The degree of differentiation was related (P 0. 01) to lymphatic metastasis (P > 0.05). Conclusion: The relationship between nm23, P53 and clinicopathological characteristics of gastrointestinal adenocarcinoma