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目的观察维持性血透析患者炎性因子与铁代谢指标的相关性。方法 85例维持性血透析患者分为A组(白细胞介素-6>5.9 pg·m L~(-1))25例、B组(白细胞介素-6≤5.9 pg·m L~(-1))30例及C组(对照组)30例。Pearson相关和逐步回归分析炎性指标和铁代谢指标之间的相关性。结果红细胞铁含量、转铁蛋白、铁调素、铁蛋白在A、B组间差异有统计学意义(P<0.05)。Pearson相关性分析发现,白细胞介素-6与铁蛋白、铁调素成正相关(均P<0.05),与红细胞铁含量、转铁蛋白、转铁蛋白饱和度成负相关(均P<0.05);高敏C反应蛋白与转铁蛋白成负相关(P<0.05)。逐步回归分析显示,铁调素、低的转铁蛋白饱和度水平与白细胞介素-6密切相关。结论维持性血透析患者微炎症状态与铁代谢紊乱有关,体内呈缺铁状态,同时还可引起铁的利用障碍。
Objective To observe the correlation between inflammatory factors and iron metabolism in maintenance hemodialysis patients. Methods Totally 85 patients with maintenance hemodialysis were divided into group A (n = 25), group B (interleukin - 6 ≤ 5.9 pg · m L ~ (-1) 1)) and 30 cases in group C (control group) 30 cases. Pearson correlation and stepwise regression analysis of the correlation between inflammatory markers and iron metabolism markers. Results The contents of erythrocyte iron, transferrin, hepcidin, and ferritin in group A and group B were significantly different (P <0.05). Pearson correlation analysis showed that interleukin-6 positively correlated with ferritin and hepcidin (all P <0.05), and had a negative correlation with iron content, transferrin and transferrin saturation of erythrocytes (all P <0.05) ; High-sensitivity C-reactive protein and transferrin negatively correlated (P <0.05). Stepwise regression analysis showed that hepcidin, low transferrin saturation levels are closely related to interleukin-6. Conclusions The micro-inflammation status of patients undergoing maintenance hemodialysis is related to iron metabolism disorders. The body is deficient in iron status and may also cause iron utilization disorders.