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为研究不同胎龄胚胎／胎儿的组织铅分布规律，本研究用大鼠作动物模型，观察了４种染毒剂量下不同胎龄大鼠组织中的铅分布。将断乳２周的雌性Ｗｉｓｔａｒ大鼠１２０只，随机分为４组，分别饮含Ｐｂ２＋浓度为０、１０、５０和２００ｍｇ／Ｌ的饮水，１０周后与正常雄鼠交配，将各组孕鼠再随机分为４个亚组，于妊娠第１０、１４、１７、２０天时处死，测孕、胎鼠组织的铅含量。结果胎鼠脑铅含量随胎龄增长而增加，但脑铅浓度保持不变；胎鼠体铅含量随胎龄增长呈增加趋势，但胎龄１０天大鼠的体铅浓度高于１４天者。胎鼠体铅含量于妊娠后期较前期明显增加；胎鼠铅含量随胎龄的增加可能与妊娠后期胎鼠体内不断出现新的铅结合位点，特别是骨骼钙化有关。
In order to study the distribution of lead in embryos and fetuses of different gestational age, the rats were used as animal models to observe the distribution of lead in different gestational age rats at four doses. One hundred and twenty female Wistar rats, weaned for 2 weeks, were randomly divided into 4 groups. Each group received drinking water containing 0, 10, 50 and 200 mg / L of Pb2 +, and mated with normal male mice 10 weeks later. The rats were randomly divided into 4 subgroups and sacrificed at the 10th, 14th, 17th and 20th days of gestation to test the lead content of the fetus and fetus. Results The content of lead in fetal rats increased with gestational age, but the concentration of lead in brain remained unchanged. The content of lead in fetal rats increased with the increase of gestational age, but the lead concentration in rats of gestational age was higher than those of 14 days . The content of lead in fetal rats increased significantly in the late gestation period. The lead content in fetal rats may be associated with new lead binding sites, especially skeletal calcification, in the second trimester of pregnancy.