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观察高压氧治疗前后慢性淤胆型肝炎患者的肝血流、临床症状、肝组织超微结构变化。采用宁波产高压氧纯氧单仓治疗３０例慢性淤胆型肝炎患者，剂量为２５ＡＴＡ，每天２ｈ，１０ｄ为１疗程，疗程间休息２ｄ，共６个疗程。治疗前后用肝血流图仪和多普勒Ｂ超测定肝血流图收缩波和门静脉右支血流量，行肝穿刺活检术。结果发现治疗后肝血流图收缩波和肝门静脉右支血流量明显升高；患者的临床症状及肝功能明显改善；治疗前后两次肝穿活检１０例中，９例肝组织汇管区淋巴细胞浸润和肝细胞淤胆减轻；８例肝细胞线粒体肿胀和ｋｕｆｅｒ细胞增生减轻；７例肝组织毛细胆管淤胆减轻和溶酶体数量减少；６例肝组织内毛细血管增生明显；治疗前后差异显著（Ｐ＜００５）。说明高压氧治疗慢性淤胆型肝炎，可增加肝动脉及门静脉右支血流量，改善患者肝脏功能和临床症状，有效地减轻肝细胞和毛细胆管淤胆及肝组织的损伤。
To observe the changes of hepatic blood flow, clinical symptoms and ultrastructure of liver in chronic cholestatic hepatitis patients before and after hyperbaric oxygen therapy. A total of 30 patients with chronic cholestatic hepatitis were treated with hyperbaric oxygen and oxygen in Ningbo. The dose was 2.5 AATA, 2 hours a day, 10 days a course of treatment, 2 days rest period, a total of 6 courses. Before and after treatment with hepatic blood flow meter and Doppler ultrasound B wave of blood flow and right portal vein contralateral blood flow, liver biopsy. The results showed that after treatment, hepatic blood flow contraction wave and portal vein right branch of the blood flow was significantly increased; patients with clinical symptoms and liver function improved significantly; before and after treatment of two biopsy in 10 cases, 9 cases of hepatic portal lymphocyte Infiltration and cholestasis of hepatocytes; edema of mitochondria and kufer cell proliferation were alleviated in 8 cases of hepatic cells; the cholestasis and the number of lysosomes were reduced in 7 cases of hepatic tissue; the proliferation of capillary vessels in 6 cases was obvious; (P <005). Hyperbaric oxygen treatment of chronic cholestatic hepatitis, can increase the right hepatic artery and portal vein blood flow, improve liver function and clinical symptoms, effectively reduce liver cells and cholestatic cholestasis and liver tissue damage.