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目的：探讨前列环素（ＰＧＩ２）、血栓素Ａ２（ＴＸＡ２）在急性坏死性胰腺炎并发肾损害发病机制中的作用。方法：采用胰胆管结扎、胰腺被膜下注射５％牛磺胆酸钠复制急性坏死性胰腺炎肾损害大鼠模型，以放射免疫方法动态测定术后２４、４８小时肾静脉血浆和肾组织中血栓素Ｂ２（ＴＸＢ２）、ＰＧＩ２水平，并观察尿素氮（ＢＵＮ）、血肌酐（ＳＣｒ）的改变。结果：随着急性坏死性胰腺炎病程进展，肾静脉血浆和肾组织中ＴＸＢ２、６酮前列腺素１α（６ｋｅｔｏＰＧＦ１α）水平逐渐升高，ＴＸＢ２水平升高较６ｋｅｔｏＰＧＦ１α为甚，ＴＸＢ２／６ｋｅｔｏＰＧＦ１α比值增大，ＢＵＮ、Ｃｒ亦显著提高。结论：ＴＸＡ２和ＰＧＩ２平衡紊乱是急性坏死性胰腺炎并发肾损害的主要因素之一。
Objective: To investigate the role of PGI2 and TXA2 in the pathogenesis of acute necrotizing pancreatitis complicated with renal damage. Methods: Rat models of renal necrosis of acute necrotizing pancreatitis were induced by pancreaticobiliary ligation and subconjunctival injection of 5% sodium taurocholate into the pancreas. The thrombus in plasma and renal tissue of renal vein at 24 and 48 hours after operation were measured by radioimmunoassay (TXB2) and PGI2 levels, and observed the changes of blood urea nitrogen (BUN) and serum creatinine (SCr). Results: With the progression of acute necrotizing pancreatitis, the levels of TXB2 and 6ketoPGF1α in renal vein were gradually increased, the level of TXB2 was higher than that of 6ketoPGF1α, the ratio of TXB2 / 6ketoPGF1α was increased, BUN, Cr also significantly increased. Conclusion: The imbalance of TXA2 and PGI2 is one of the main causes of renal damage in acute necrotizing pancreatitis.