白细胞介素Ⅱ联合加温化疗治疗癌性腹腔积液

• 作 者: 周成英
• 机 构: 江苏省盐城市第一人民医院
• 出 处: 肿瘤研究与临床
• 发表日期: 1998年02期
• 关键词: 白细胞介素Ⅱ 腹腔积液 癌性 尿嘧啶 腹腔内灌注 加温化疗 温热化疗 生存质量 相加作用 分组方法

１９９５年始采用随机分组方法，比较白细胞介素Ⅱ与加温顺铂、５－氟尿嘧啶联合（治疗组）及单用顺铂、５－氟尿嘧啶（对照组）腹腔内灌注治疗癌性腹腔积液４３例，结果显示：治疗组有效率为９０．９％，对照组有效率为６１．９％，Ｐ＜０．０５。生存质量方面治疗组明显提高，Ｐ＜０．０５。两组毒副反应均较轻，Ｐ＞０．０５无显著性差异，结论：白细胞介素Ⅱ与加温顺铂、５－氟尿嘧啶联合腹腔灌注治疗癌性腹腔积液，可能有协同、相加作用，是有效、简便、毒副反应小的治疗手段

In 1995, a randomized method was used to compare 43 cases of cancerous ascites treated with intraperitoneal infusion of interleukin II and warmed cisplatin and 5-fluorouracil (treated group) and cisplatin alone and 5-fluorouracil (control group). The results showed that the effective rate was 90.9% in the treatment group and 61.9% in the control group, P<0.05. The quality of life in the treatment group was significantly improved, P<0.05. The toxicities and side effects of the two groups were mild, P>0.05 had no significant difference. Conclusion: Interleukin II combined with warm cisplatin, 5-fluorouracil and intraperitoneal perfusion in the treatment of cancerous ascites, may have synergy, add The effect is a treatment that is effective, simple, and has a low toxicity.