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近年研究发现脓毒血症死亡并非完全由过度炎症所致,脓毒血症患者血液中不但有大量的促炎细胞因子,抗炎因子也显著增加,导致免疫抑制。患者的免疫状态在脓毒血症发生、发展过程中处于免疫细胞过度激活和淋巴细胞受抑制的双向异常或紊乱状态。机体发生免疫功能紊乱,有害因子大量释放,巨噬细胞抗原递呈功能受损,难以对入侵微生物发生免疫反应,最终形成多器官功能不全综合征。所以需要对脓毒血症免疫功能紊乱进行研究,以制订治疗方案,防止病情恶化。
In recent years, studies have found that the death of sepsis is not completely caused by excessive inflammation. In patients with sepsis, there are a large number of proinflammatory cytokines and anti-inflammatory cytokines in the blood, leading to immunosuppression. The patient’s immune status occurs in sepsis and develops in a bidirectional abnormal or disturbed state of over-activation of immune cells and suppression of lymphocytes. Immune dysfunction occurs in the body, a large number of harmful factors released, macrophage antigen presentation was impaired, it is difficult to invading microorganisms immune response, the final formation of multiple organ dysfunction syndrome. So we need to study the immune function of sepsis to develop treatment options to prevent the disease from deteriorating.