Synthesis of 2-(Benzodioxol-2-yl)acetic Acids as PPARδ Agonists

• 作 者: Jian Lei KANG Zhi Bing ZHENG D
• 机 构: School of Pharmaceutical Engineering,Institute of Pharmacology and Toxicology
• 出 处: 中国化学快报（英文版）
• 发表日期: 2004年期
• 关键词: PPARδ agonists 2-(benzodioxol-2-yl)acetic acids synthesis
• 基金项目: 国家自然科学基金;国家高技术研究发展计划(863计划)

A new series of compounds, 2-(benzodioxol-2-yl)acetic acids, have been synthesized. Their structures were confirmed by MS and 1H-NMR. The preliminary pharmacological screening showed that these compounds exhibited potent human PPARδ agonist activities.