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目的观察普兰林肽配合甘精胰岛素治疗2型糖尿病的临床效果。方法将56例符合2型糖尿病诊断标准的糖尿病患者随机分为试验组和对照组,对照组单纯采用胰岛素治疗,观察组以甘精胰岛素配合普兰林肽治疗。两组患者均于治疗前及治疗后测定FBG、2hPG、HbAlc、FINS、IRI、BP水平并观察低血糖发生情况。结果治疗后两组患者各血糖监测指标均较治疗前有显著下降(P<0.05);试验组FBG、2hPG、HbAlc、FINS、IRI、BP等指标下降幅度均大于对照组,差异有统计学意义(P<0.05);试验组低血糖发生率显著低于对照组,差异有统计学意义(P<0.05)。结论甘精胰岛素配合普兰林肽治疗2型糖尿病临床疗效确切,且能改善低血糖发生,效果优于单独使用胰岛素。
Objective To observe the clinical effect of pramlintide combined with insulin glargine in the treatment of type 2 diabetes mellitus. Methods Fifty-six diabetic patients with type 2 diabetes mellitus were randomly divided into experimental group and control group. The control group was treated with insulin only, and the observation group with insulin glargine and pramlintide. The levels of FBG, 2hPG, HbA1c, FINS, IRI and BP in both groups before and after treatment were measured and the incidence of hypoglycemia was observed. Results After treatment, the indexes of blood glucose monitoring in both groups were significantly lower than those before treatment (P <0.05). The decreasing rates of FBG, 2hPG, HbAlc, FINS, IRI and BP in the experimental group were all significantly lower than those in the control group (P <0.05). The incidence of hypoglycemia in the experimental group was significantly lower than that in the control group (P <0.05). Conclusion Glargine and pramlintide treatment of type 2 diabetes clinical efficacy is exact, and can improve the incidence of hypoglycemia, the effect is better than the single use of insulin.