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目的研究不明原因复发性流产患者免疫治疗前后的封闭抗体(BA)变化及其妊娠结局。方法封闭抗体阴性的复发性流产患者采用丈夫外周血淋巴细胞主动免疫治疗,比较治疗前后封闭抗体变化,并比较接受免疫治疗与未接受治疗的妊娠成功的患者的妊娠结局。结果主动免疫治疗后封闭抗体阳性率为72.91%;接受免疫治疗者妊娠成功率为68.86%,BA阴性未接受免疫治疗者妊娠成功率为27.13%,差异有统计学意义;免疫治疗后封闭抗体阳性者妊娠成功率达82.95%,免疫治疗后BA阴性者妊娠成功率为34.93%,差异有统计学意义;两组患者病理妊娠结局、新生儿畸形率差异无统计学意义。结论封闭抗体缺乏是不明原因复发性流产的一个重要原因,淋巴细胞主动免疫治疗是比较有效的治疗手段。
Objective To study the change of blocking antibody (BA) before and after immunotherapy in patients with unexplained recurrent spontaneous abortion and its pregnancy outcome. Methods Closed antibody-negative recurrent spontaneous abortion patients using active immunotherapy of peripheral blood lymphocytes of husbands, compared before and after treatment of closed antibody changes, and compared with immunotherapy and no treatment of pregnancy success in patients with pregnancy outcome. Results The positive rate of blocking antibody after active immunotherapy was 72.91%. The success rate of pregnancy with immunotherapy was 68.86%. The success rate of pregnancy with BA negative immunotherapy was 27.13%, the difference was statistically significant. The antibody positive after immunization The success rate of pregnancy was 82.95%, BA negative pregnancy rate after immunotherapy was 34.93%, the difference was statistically significant; two groups of patients with pathological pregnancy outcome, neonatal deformity rate difference was not statistically significant. Conclusion Closed antibody deficiency is an important reason for unexplained recurrent spontaneous abortion. Active immunotherapy with lymphocytes is an effective treatment.