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目的通过早期监测新生儿血清胆红素(SB),预测新生儿的黄疸程度。方法(1)用微量法出生后1~3d的SB水平值,其中560例正常足月儿为正常组,221例有明显黄疸病因的不同程度黄疸的足月新生儿为黄疸组,比较两组的SB水平值。(2)将黄疸组的新生儿按病因分为ABO溶血组、感染组、G6PD缺陷组、母乳性黄疸组、母亲为HBsAg阳性组,分析比较其各组出生后1~3dSB水平。结果(1)黄疸组出生后1、2、3d的SB值分别为(94.51±24.60)、(177.48±43.04)、(229.10±42.96)μmol/L,均明显高于正常组(P<0.01)。(2)黄疸组出生后1dSB>103μmol/L的发生率为29.86%,出生后2dSB>154μmol/L的发生率为66.97%,出生后3dSB>205μmol/L的发生率为53.85%,均高于正常组(P<0.01)。(3)在5组比较中出生后1d和2d的SB值经F检验,差别有统计学意义(P<0.05)。结论早期监测SB值,可预测新生儿黄疸及黄疸程度。
Objective To monitor the neonatal jaundice by early monitoring of serum bilirubin (SB) in neonates. Methods (1) SB level of 1 ~ 3d after birth was detected by micro-method, of which 560 normal term children were normal group, 221 full-term newborns with jaundice with obvious jaundice etiology were jaundice group, SB level. (2) The newborns of jaundice group were divided into ABO hemolysis group, infection group, G6PD deficiency group, breast milk jaundice group and mothers HBsAg positive group by etiology. The levels of 1 ~ 3dSB in each group were analyzed. Results The SB values of jaundice group at 1, 2 and 3 days after birth were (94.51 ± 24.60), (177.48 ± 43.04) and (229.10 ± 42.96) μmol / L, respectively, which were significantly higher than those in normal group (P <0.01) . (2) The incidence of SBS> 103μmol / L at 1d after birth in jaundice group was 29.86%, the incidence of SBS> 154μmol / L at 2d after birth was 66.97%, and the incidence of 3dSB> 205μmol / L after birth was 53.85% Normal group (P <0.01). (3) The SB values of 1d and 2d after birth in the 5 groups were statistically significant (P <0.05) by F test. Conclusion Early monitoring of SB values can predict neonatal jaundice and jaundice.