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目的:观察阿托伐他汀治疗不稳定型心绞痛疗效及其对内皮素-1(endothelin-1,ET-1)和一氧化氮(nitric oxide,NO)的影响。方法:将不稳定型心绞痛患者随机分为治疗组(n=45)和对照组(n=45),2组均给予同样的常规治疗,治疗组加用阿托伐他汀,均治疗2个月后观察治疗前后心绞痛疗效,检测ET-1和NO水平变化。结果:治疗组可以改善心绞痛症状,降低ET-1水平,提高NO水平,与对照组比较差异有统计学意义(P<0.05或P<0.01)。结论:阿托伐他汀可以通过调节内皮功能,稳定冠状动脉粥样硬化斑块,从而改善心绞痛临床症状。
Objective: To observe the curative effect of atorvastatin on unstable angina pectoris and its effect on endothelin-1 (ET-1) and nitric oxide (NO). Methods: Patients with unstable angina pectoris were randomly divided into treatment group (n = 45) and control group (n = 45). Both groups received the same routine treatment. The treatment group received atorvastatin for 2 months The effect of angina pectoris before and after treatment was observed, and the changes of ET-1 and NO levels were detected. Results: The treatment group could improve the symptoms of angina pectoris, reduce the level of ET-1 and increase the level of NO, the difference was statistically significant (P <0.05 or P <0.01). Conclusion: Atorvastatin can improve the clinical symptoms of angina pectoris by regulating endothelial function and stabilizing coronary atherosclerotic plaque.