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近年来,国内外对免疫球蛋白的用途又有新的发现,给药途径也从肌注发展为口服、静脉给药及雾化吸入等,使其在儿科临床中有了更广泛的应用,现综述如下: 1 防治川畸病(KD)心血管损害:KD被认为是由逆转录病毒引起的一种幼儿易患的疾病,而冠状动脉瘤与心肌梗塞常为KD的致死原因。临床观察表明,单用阿期匹林治疗者冠状动脉损伤发生率高,为18％,而加用静脉用免疫球蛋白(IVIg)可降低其发生率至4％。冠状动脉损害与发热持续时间呈正相关,
In recent years, the use of immunoglobulin at home and abroad have new discoveries, administration routes from intramuscular injection to oral, intravenous administration and inhalation of nebulization, so that it has been more widely used in pediatric clinical, Are summarized as follows: 1 prevention and treatment of Kawasaki disease (KD) cardiovascular damage: KD is considered as a predisposing disease caused by retrovirus, and coronary artery aneurysm and myocardial infarction are often the cause of death of KD. Clinical observations showed that the incidence of coronary artery injury in patients treated with aspirin alone was high at 18%, whereas the addition of intravenous immunoglobulin (IVIg) reduced the incidence to 4%. Coronary artery lesions and fever duration was positively correlated,